منابع مشابه
Toll-Like receptors (TLRs) and their ligands.
The innate immune system is an evolutionally conserved host defense mechanism against pathogens. Innate immune responses are initiated by pattern recognition receptors (PRRs), which recognize microbial components that are essential for the survival of the microorganism. PRRs are germline-encoded, nonclonal, and expressed constitutively in the host. Different PRRs react with specific ligands and...
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Female and male reproductive tracts are of interest sites to study of immune system because they encounter specific infections such as those are sexually transmitted. Furthermore, female reproductive tract is in close contact with allogenic sperms and transmitted microorganisms during intercourse and semi allogenic fetus during pregnancy. In mammals, there are two types of immune responses, the...
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Toll-like receptors (TLRs) are highly conserved trans-membrane proteins that play an important role in the detection and recognition of microbial pathogens. The key product of TLR signalling in antigen presenting cells is the production of inflammatory cytokines and proteins. The TLR pathway plays an important role in mediating whole body inflammation, which has been implicated in the developme...
متن کاملToll like Receptors (TLRs) expression in HIV children
Results Mean age of study population was 8.08 ± 3.41 years. 75% of patients were in WHO clinical stage I and II, whereas 25% in stage III. 29% HIV children had severe immunosuppression. TLR-1 showed neutral expression in majority (96%) of HIV children. For TLR-7, 53.5% HIV children showed upregulation, whereas 32% and 14.5% showed downregulation and neutral expression, respectively. TLR-8 expre...
متن کاملToll-Like Receptors (TLRs): The Role in Tumor Progression
Toll-like receptors (TLRs) are major components of the innate immune system that recognize the conserved molecular structures of pathogens (pathogen-associated molecular patterns; PAMPs). TLRs are found in many different cell types, ranging from epithelial to immunocompetent cells. TLR binding triggers the expression of several adapter proteins and downstream kinases, leading to the induction o...
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ژورنال
عنوان ژورنال: Journal of Leukocyte Biology
سال: 2019
ISSN: 0741-5400,1938-3673
DOI: 10.1002/jlb.2ce0619-184r